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The Seminar is hosted by Biological Sciences Department for Biology Seminar Series - Fall22 . We are inviting Dr. Dr. Kathryn M. Ramsey from The University of Rhode Island.
Control of Virulence in the Bacterial Pathogen and Potential Bioweapon Francisella tularensis
In the human pathogen Francisella tularensis, we have determined that changes in ribosome protein composition govern virulence gene expression. Our results indicate that ribosome composition in F. tularensis, either directly or indirectly, posttranscriptionally modulates gene expression and virulence. Our findings are consistent with a model in which a particular ribosomal protein homologs function as posttranscriptional regulators, allowing preferential translation of specific subsets of mRNAs. Our work also raises the possibility that ribosome heterogeneity may permit many bacteria to posttranscriptionally regulate gene expression.
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