Comet Calendar

Neuroscience Seminar Series

Title: Stem Cell Approaches to Understanding Acquired and Genetic Epilepsies

Speaker:
Jenny Hsieh, PhD
UT San Antonio

The Hsieh lab focuses on the mechanisms that promote neural stem cell self-renewal and differentiation in embryonic and adult brain. Using mouse models, video-EEG monitoring, viral techniques, and imaging/electrophysiological approaches, we elucidated many of the key transcriptional/epigenetic regulators of adult neurogenesis and showed aberrant new neuron integration in adult rodent hippocampus contribute to circuit disruption and seizure development. Building on this work, I will present our recent studies describing how GABA-mediated Ca2+ activity regulates the production of aberrant adult-born granule cells. In a second direction of my laboratory, we are using human induced pluripotent stem cells and brain organoid models as approaches to understand brain development and disease. Mutations in one gene, Aristaless-related homeobox (ARX), are of considerable interest since they are known to cause a common spectrum of neurodevelopmental disorders including epilepsy, autism, and intellectual disability. We have generated cortical and subpallial organoids from patients with poly-alanine expansion mutations in ARX. To understand the nature of ARX mutations in the organoid system, we are currently performing cellular, molecular, and physiological analyses. I will present these data to gain a comprehensive picture of the effect of ARX mutations in brain development. Since we do not understand how human brain development is affected by ARX mutations that contribute to epilepsy, we believe these studies will allow us to understand the mechanism of pathogenesis of ARX mutations, which has the potential to impact the diagnosis and care of patients.

On November 9 2023 at 4:00 - 5:00PM
In-person in CRA 12.110.

Host: Lena Nguyen, PhD

This will also be available on MS Teams.
Meeting ID: 274 369 202 427
Passcode: Rmj9NR

CRA 12.110

Behavioral and Brain Sciences
Jennifer Morina
Email
972-883-2448

UTD strives to create inclusive and accessible events in accordance with the Americans with Disabilities Act (ADA). If you require an accommodation to fully participate in this event, please contact the event coordinator (listed above) at least 10 business days prior to the event. If you have any additional questions, please email ADACoordinator@utdallas.edu and the AccessAbility Resource Center at accessability@utdallas.edu.

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