Comet Calendar
The Integrated Stress Response Regulates Pain Hypersensitivity - Neuroscience Seminar Series
Thursday, December 12, 2024 4pm to 5pm
Event Details
Neuroscience Seminar Series
Title: The Integrated Stress Response Regulates Pain Hypersensitivity
Speaker:
Muhammad Saad Yousuf, PhD (Faculty Candidate)
UT Dallas
The integrated stress response (ISR) is an adaptive response to various cellular stressors, including unfolded proteins, viral infection, and inflammation. The ISR acts as a central mechanism that underlies pain hypersensitivity in diabetes and Multiple Sclerosis (MS). Methylglyoxal (MGO) is a reactive glycolytic metabolite elevated in the plasma of patients suffering from neuropathic pain. By investigating how MGO triggers ISR, I aim to uncover the role of translational control mechanisms, particularly those regulated by eIF2A, that cause nociceptor hyperexcitability and pain. Using techniques like TRAP-seq and human tissue models, I will identify molecular targets to improve the understanding of diabetic neuropathy and MS with the goal of clinical translation. I will also explore innovative, non-opioid analgesics, such as TMEM97 modulators, to inhibit ISR and develop effective treatments for diabetic and MS neuropathic pain, addressing significant unmet clinical needs.
On December 12, 2024 at 4:00 - 5:00PM
In-person in CRA 12.110.
This will also be available on MS Teams.
Meeting ID: 284 214 784 797
Passcode: v8buG5
Location
CRA 12.110
Department
- Behavioral and Brain Sciences
Contact Information
- Jennifer Morina
- 972-883-2448
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Target Audience
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Undergraduate Students, Prospective Students, Graduate Students
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Accessibility
UTD strives to create inclusive and accessible events in accordance with the Americans with Disabilities Act (ADA). If you require an accommodation to fully participate in this event, please contact the event coordinator (listed above) at least 10 business days prior to the event. If you have any additional questions, please email ADACoordinator@utdallas.edu and the AccessAbility Resource Center at accessability@utdallas.edu.
