Comet Calendar

The Central Amygdala as the Detector and Regulator of Inflammatory Pain - Neuroscience Seminar Series

Thursday, November 5, 2020 4pm to 5pm

Virtual Event

Neuroscience Seminar Series

Title - The Central Amygdala as the Detector and Regulator of Inflammatory Pain

Speaker:

Dr. Fusao Kato
Jikei University, Japan

Graduated from The University of Tokyo in 1982 and received PhDs from the Graduate School of the University of Tokyo in 1989 and the Jikei University School of Medicine in 1997. Foreign Researcher at CNRS, France (1993-1995), Professeur associé at l'Université Louis Pasteur, Strasbourg, France (1995-1996; 1998), and Invited Researcher in University of Sheffield, UK (2001). Full Professor of Jikei University School of Medicine since 2005. Currently the Director of the Department of Neuroscience and the Chairman of the Center for Neuroscience of Pain in the Jikei University of Medicine. Member of the Science Council of Japan. Ex-Vice President of the Physiological Society of Japan and Board Member of the Japanese Association for Study of Pain.

On Nov. 5 at 4:00pm, join the talk on MS Teams.
Conference ID: 906 672 31#

Abstract:
Nociceptive information is conveyed to the central amygdala (CeA) directly through relays at the spinal dorsal horn/trigeminal spinal nucleus and the parabrachial nucleus. In 2007, we reported that the synaptic transmission from the lateral parabrachial nucleus (LPB) to the capsular part of the central amygdala (CeC) is potentiated in spinal nerve ligation model of rats with a strong correlation with the allodynia in the contralateral hind limb (Ikeda et al, 2007). This potentiation, but not the mechanical allodynia, depended on C-fiber activation (Nakao et al, 2012), leading us to an idea of the involvement of inflammatory processes. Thus, we moved to use "latent" inflammatory pain model with formalin, which resulted in more robust, developing, and long-lasting activation of the LPB and CeC neurons, as revealed with Fos expression analysis, optogenetics, chemogenetics, and MRI techniques (Sugimura et al, 2016; Shinohara et al, 2017; Miyazawa et al, 2018; Arimura et al, 2019). This model presented 1) predominant activation of the right CeC and 2) ectopic allodynia in the site remote from the site of inflammation in a manner dependent on CeA activity. Our idea is that nociceptive signals converge to the central amygdala together with inflammatory information, which in turn regulates the nociception sensitivity at wide areas of the body, thus contributing to avoiding further forthcoming harmful events.

Virtual Event

Behavioral and Brain Sciences

UTD strives to create inclusive and accessible events in accordance with the Americans with Disabilities Act (ADA). If you require an accommodation to fully participate in this event, please contact the event coordinator (listed above) at least 10 business days prior to the event. If you have any additional questions, please email ADACoordinator@utdallas.edu and the AccessAbility Resource Center at accessability@utdallas.edu.

  • Alyssa Ortega
  • Rachna Raman
  • David Kam

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