Psychology Lecture Series - In-Person and Virtual Event

Title - Distinct Effects of Alzheimer’s Disease Dementia Severity and Aging on the Segregation of Functional Brain Networks at Rest

Speaker: Ziwei Zhang
PhD Student, UT Dallas

Alzheimer’s disease (AD) is the most common cause of dementia. Adult aging is the biggest risk factor for developing late-onset AD. Age and AD are associated with less segregated resting-state functional brain networks. A debate exists about whether the process of AD dementia shares commonality with the aging process. We tested this hypothesis by comparing the effects of AD dementia severity and age on resting-state brain system segregation. Participants included in this study are part of the Alzheimer’s Disease Neuroimaging Initiative (ADNI). We used clinical dementia rating (CDR) as a measure to quantify AD dementia severity and performed analyses to evaluate how brain system segregation varies in relation to an individual’s CDR status and age. The results demonstrate that age and AD dementia severity are independently related to altered functional network organization. Aging and dementia may exert impacts on unique and non-overlapping sets of functional brain systems. 

This talk is in-person in JO 4.306 and also is a virtual event. At 2:30pm on October 25, join the talk on MS Teams.
Conference ID: 215 749 170 982
Passcode: Xdf32T